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雌激素治疗可改善自身免疫性关节炎、实验性脑炎等多种自身免疫性疾病,而CD4+CD25+调节性T细胞(Treg)是机体发挥免疫抑制作用的一群重要的细胞。研究表明,雌激素能增加Treg数目并增强其抑制功能,发挥减轻免疫反应、炎症等作用;雌激素能够通过多种渠道促进Treg。本文综述了雌激素对Treg的影响和作用机制,这是雌激素发挥免疫治疗作用的重要机制之一。
Estrogen therapy can improve autoimmune arthritis, experimental encephalitis and other autoimmune diseases, and CD4 + CD25 + regulatory T cells (Treg) is the role of the body to play an important group of immunosuppressive cells. Studies have shown that estrogen can increase the number of Treg and enhance its inhibitory function, play a role in reducing immune response, inflammation and so on; estrogen through a variety of channels to promote Treg. This article reviews the effects of estrogen on Treg and its mechanism of action, which is one of the important mechanisms by which estrogen plays an immunotherapy role.