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目的:探讨妊娠相关蛋白A(PAPP-A)与冠心病及斑块易损性之间的关系。方法:选择急性冠状动脉综合征(ACS组)患者20例,稳定性心绞痛(SAP组)患者19例,采用ELISA测定患者血清中PAPP-A水平,同时应用光学相干断层成像技术测定患者斑块纤维帽厚度。结果:ACS组PAPP-A高于SAP组[(48.71±18.90)ng/L∶(18.93±11.11)ng/L,P<0.01];ACS组斑块纤维帽厚度低于SAP组[(45.44±18.25)μm∶(90.74±24.54)μm,P<0.01]。ACS组中PAPP-A与斑块纤维帽厚度呈负相关,r=-0.778,P<0.01。逐步(Stepwise)多重线性回归分析认定PAPP-A是预测斑块易损性的一种独立危险因素。结论:PAPP-A是一种独立的、能够有效预测冠心病风险以及斑块易损性的标记物。
Objective: To investigate the relationship between pregnancy-associated protein A (PAPP-A) and coronary heart disease and plaque vulnerability. METHODS: Twenty patients with acute coronary syndrome (ACS) and 19 patients with stable angina (SAP) were enrolled in this study. PAPP-A levels were measured by ELISA in patients with coronary artery disease (CAD). Meanwhile, optical coherence tomography Cap thickness. Results: The PAPP-A level in ACS group was significantly higher than that in SAP group [(48.71 ± 18.90) ng / L: (18.93 ± 11.11) ng / L, P <0.01] 18.25) μm: (90.74 ± 24.54) μm, P <0.01]. PAPP-A in ACS group was negatively correlated with plaque cap thickness, r = -0.778, P <0.01. Stepwise multiple linear regression analysis identified PAPP-A as a predictor of plaque vulnerability as an independent risk factor. Conclusion: PAPP-A is an independent marker that can predict coronary heart disease risk and plaque vulnerability.