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脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是广泛分布于神经系统的一种神经营养因子,人BDNF基因位于11q13。近年来研究发现,BDNF及其受体在人卵巢中也有表达,它经由旁分泌和自分泌方式,通过与促性腺激素、卵巢甾体激素的相互作用,影响卵泡生成和生长、卵子成熟、排卵和早期胚胎的发育等过程。多囊卵巢综合征和卵巢储备功能减退女性卵泡液中的BDNF分泌异常,这可能与卵泡内活性氧增加和过度的氧化应激有关,对BDNF与多囊卵巢综合征、卵巢储备功能减退关系的研究可能有助于揭示排卵异常性不孕的部分发病机制。
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor widely distributed in the nervous system. The human BDNF gene is located at 11q13. In recent years, studies have found that BDNF and its receptors are also expressed in human ovary, which through paracrine and autocrine mode, through the interaction with gonadotropin, ovarian steroid hormone affect the generation and growth of follicles, egg maturation, ovulation And early embryonic development process. Abnormal secretion of BDNF in follicular fluid of women with polycystic ovary syndrome and ovarian reserve dysfunction may be related to the increase of reactive oxygen species (ROS) and excessive oxidative stress in follicles, and the relationship between BDNF and polycystic ovary syndrome and ovarian reserve loss Research may help reveal part of the pathogenesis of abnormal ovulation infertility.