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应用核仁组成区相关蛋白（ＡｇＮｏＲｓ）染色观察５２例不同类型肠上皮化生（简称肠化生），１１例中重度异型增生、３０例胃窦癌及４例正常胎儿胃粘膜和２０例正常胃粘膜ＡｇＮＯＲ量的变化，发现Ⅲ型肠化生ＡｇＮＯＲ计数显著高于Ⅰ、Ⅱ型肠化生（Ｐ＜０．０５）。从正常胃粘膜上皮，经肠上皮化生到中重度异型增生到胃癌，ＡｇＮＯＲ计数随细胞异型程度的加重而递增，各组间均见显著性差异（Ｐ＜０．０５）。结果表明，Ⅲ型肠化生与胃癌的发生有密切关系，具有较高ＡｇＮＯＲ计数的中重度异型增生是重要的癌前病变。
AgNOR staining was used to observe 52 cases of intestinal metaplasia (intestinal metaplasia), 11 cases of moderate-to-severe dysplasia, 30 cases of gastric antrum cancer, 4 cases of normal fetal gastric mucosa and 20 cases of normal Changes in the amount of AgNOR in gastric mucosa showed that AgNOR counts in type III intestinal metaplasia were significantly higher than those in type I and II intestinal metaplasia (P<0.05). From normal gastric mucosa epithelium, from intestinal epithelial metaplasia to moderately severe dysplasia to gastric cancer, AgNOR counts increased with the increase in the degree of heterogeneity of the cells, with significant differences between the groups (P<0.05). The results showed that type III intestinal metaplasia is closely related to the occurrence of gastric cancer. Moderate to severe dysplasia with high AgNOR count is an important precancerous lesion.