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目的:探讨Y染色体无精子因子(AZF)微缺失在习惯性流产夫妇中的发生情况。方法:采用聚合酶链反应技术对7例习惯性流产夫妇中的男性Y染色体上AZF基因(STS)上的3个位点SY157、SY254、SY255及ZFX/ZFY基因进行检测。结果:7例男性中的1例(14.29%)在所检测的3个位点有1处缺失,10例可生育且无流产史的男性未见任何微缺失。结论:习惯性流产夫妇中男性AZF缺失可能是造成习惯性流产的一个原因,两者有一定的相关性。
Objective: To investigate the occurrence of Y chromosome Azoospermia (AZF) microdeletions in habitual abortion couples. Methods: SY157, SY254, SY255 and ZFX / ZFY genes were detected in 3 sites of AZF gene (STS) in 7 male abortion couples by polymerase chain reaction (PCR). Results: One of 7 males (14.29%) had one deletion at 3 sites tested, and none of the 10 males with fertility history and no history of abortion had any microdeletions. Conclusion: The loss of male AZF in habitual abortion couples may be one of the reasons for habitual abortion, and the two are related to each other.