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目的 分析晚期结直肠癌患者中医证型、中医体质与其生存结局之间的相关性.方法 采用回顾性病例对照研究方法,对中国中医科学院西苑医院肿瘤科杨宇飞教授门诊晚期(Ⅳ期)结直肠癌连续病例进行筛选,按生存时间确定劣势生存组(劣势组)19例,按年龄、性别、肿瘤部位配比优势生存组(优势组)76例.利用x2检验以及Logistic回归分析中医证型、体质与晚期结直肠癌优、劣势生存结局的相关性.结果 劣势组肝脾不和证比例[53％(10/19)]高于优势组[20％ (15/79),P=0.004],优势组中血瘀体质比例[26％ (20/79)]高于劣势组[5％(1/19),P=0.048],而优势组阳虚体质比例[1％(1/79)]则低于劣势组[11％(2/19),P=0.04].肝脾不和证与血瘀体质均为劣势生存的独立预后因素(P分别为0.01和0.03).结论 中医证型和体质特征因素与晚期结直肠癌预后相关.“,”Objective To evaluate the relationship between Chinese Medicine (CM) syndrome,body condition and survival outcomes of advanced colorectal cancer (CRC) patients.Methods This retrospective case-control study was conducted among continuous advanced (stage Ⅳ) CRC patients samples from Professor Yang Yu-fei oncology clinic in Xiyuan Hospital of China Academy of Chinese Medical Sciences.By follow-up and retrospectively screening,the study enrolled 19 stage Ⅳ CRC patients into disadvantage survival group (disadvantage group) according to overall survival time,and 76 stage Ⅳ CRC patients into advantage survival group (advantage group) matched by age,gender and tumor location.The relationship between CM syndromes,body conditions and survival outcome were investigated by Chi-square test and Logistic regression model.Results Among all the patients,the incidence of Gan and Pi disharmony syndrome was significant higher in disadvantage group[53％ (10/19)] than in advantage group [20％(15/79),P =0.004],while the blood stagnation condition was significant higher in advantage group [26％ (20/79)] than in disadvantage group [5％ (1/19),P =0.048],however Yang deficiency condition was significantly less in advantage group [1％ (1/79)] than in disadvantage group [11％ (2/19),P =0.04].Gan and Pi disharmony syndrome and blood stagnation were independently related to disadvantage survival outcomes for advanced CRC patients (P =0.01 and 0.03 respectively).Conclusion CM syndrome and body condition were associated with survival outcomes of advanced CRC patients.