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目的 探讨转化生长因子β1 (TGF-β1 )和口腔鳞癌侵袭及转移的关系。方法 应用酶联免疫吸附法测定 40例口腔鳞癌根治性手术前后患者血清 TGF- β1 浓度 ;免疫组化法分析癌灶组织的 TGF- β1 蛋白表达水平。结果 伴有颈淋巴结转移组的血清 TGF- β1 浓度和 TGF- β1 蛋白表达水平高于无淋巴结转移组 (P<0 .0 5～ 0 .0 1) ,切除癌灶后上述各组的血清 TGF- β1 浓度均明显下降 (P<0 .0 5 )。结论 TGF- β1 可能与人口腔鳞癌的侵袭和转移有密切关系
Objective To investigate the relationship between transforming growth factor β1 (TGF-β1) and invasion and metastasis of oral squamous cell carcinoma. Methods Serum levels of TGF-β1 in 40 patients with oral squamous cell carcinoma before and after radical surgery were measured by enzyme-linked immunosorbent assay (ELISA). The expression of TGF-β1 protein in cancer tissue was detected by immunohistochemistry. Results Serum levels of TGF-β1 and TGF-β1 in cervical lymph node metastasis were higher than those without lymph node metastasis (P <0.05-0.01). Serum TGF - β1 concentrations were significantly decreased (P <0.05). Conclusion TGF-β1 may be closely related to the invasion and metastasis of oral squamous cell carcinoma