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目的 :研究 99m Tc-甲氧基异丁基异腈 (99m Tc- MIBI)显像鉴别诊断乳腺肿物的良、恶性及探测腋淋巴结转移的情况。方法 :对 5 1例可触及的乳腺肿物及 11例乳腺癌术后疑腋淋巴结转移患者分别于注射 99m Tc- MIBI后 10和 6 0 m in行平面显像 ,半定量分析肿物部位的摄取比值 (uptake ratio,U R) ,均与病理结果对比。 结果 :99m Tc- MIBI平面显像对可触及的乳腺肿物诊断乳腺癌的敏感性为 93.3% ,特异性为 95 .2 % ;阳性预测值为 96 .6 % ,阴性预测值为 90 .9%。探测腋淋巴结转移的敏感性为 6 4.0 % ,特异性为 94.1% ;阳性预测值为 94.1% ,阴性预测值为 6 4.0 %。结论 :99m Tc- MIBI平面显像鉴别乳腺肿物的良、恶性及探测腋淋巴结转移有较高的敏感性和特异性。
Objective : To study 99m Tc-MIBI imaging in the differential diagnosis of benign and malignant breast tumors and to detect axillary lymph node metastasis. METHODS: A total of 51 patients with palpable breast masses and 11 patients with suspected metastatic lymph nodes after breast cancer surgery were treated with 99m Tc-MIBI 10 and 60 mm in-line plain imaging, respectively, to semi-quantitatively analyze the location of the masses. The uptake ratio (UR) was compared with pathological results. RESULTS: The 99m Tc-MIBI planar imaging showed a sensitivity of 93.3% and a specificity of 95.2% for predicting breast cancer in palpable breast tumors. The positive predictive value was 96.6 % and the negative predictive value was 90.9. %. The sensitivity of detection of axillary lymph node metastasis was 64.0%, the specificity was 94.1%, the positive predictive value was 94.1%, and the negative predictive value was 6 4.0%. Conclusion: 99m Tc-MIBI planar imaging has high sensitivity and specificity in distinguishing benign and malignant breast tumors and detecting axillary lymph node metastases.