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目的 观察雷莫司琼（奈西雅）预防化疗药物［顺铂和（或）阿霉素］所致胃肠反应的作用，并与格拉司琼（康泉）对比，观察两药的疗效和安全性。方法 采用随机、交叉、自身对照方法。入选病人随机分为ＡＢ组或ＢＡ组。ＡＢ组第１周期给予奈西雅，第２周期给予康泉；ＢＡ组第１、２周期给药顺序则相反。结果 可评价疗效４０例。在化疗后１２小时内奈西雅对食欲缺乏的控制率（７０％）及２４小时内对恶心的抑制作用（５７．５％）明显优于康泉（４７．５％，３７．５％），差异有显著性（Ｐ＜０．０５）。奈西雅不良反应轻，主要为头重感、头痛、口干、疲倦等，其发生率与康泉相似。结论 奈西雅能有效地预防化疗药物所致胃肠反应，其对食欲缺乏及恶心的抑制作用优于康泉。不良反应轻，是良好的止吐药。
Objective To observe the effect of ramosetron (Neethia) on preventing gastrointestinal reactions caused by chemotherapy drugs [cisplatin and/or adriamycin] and compare it with granisetron (Kangquan) to observe the efficacy of the two drugs and safety. Methods Randomized, crossover, self-control methods were used. Selected patients were randomly assigned to either AB or BA groups. The first cycle of the AB group was given to Neisseria, and the second cycle was given to Kangquan; the first and second cycles of the BA group were reversed. Results Efficacy can be evaluated in 40 cases. The control rate of appetite deficiency (70%) and the inhibition of nausea within 24 hours (57.5%) were significantly better than those of Kang Quan (47.5%, 37.5%) within 12 hours after chemotherapy. The difference was significant (P<0.05). Naxisia has a mild adverse reaction, which is mainly a sense of top-heavyness, headache, dry mouth, and fatigue, and its incidence is similar to that of Kang Quan. Conclusion Neisseria can effectively prevent gastrointestinal reactions caused by chemotherapeutic drugs, and its inhibitory effect on anorexia and nausea is better than that of Kangquan. Mild adverse reactions are good antiemetic drugs.