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为观察脂质过氧化损伤对细胞粘附分子表达的影响，用联胺诱发培养的人血管内皮细胞脂质过氧化后，检测其丙二醛含量及单核细胞粘附率，并用激光共聚焦显微镜观察细胞粘附分子表达的情况。结果发现，实验组较对照组内皮细胞丙二醛含量升高，单核细胞粘附率显著增加（P＜0．01），内皮细胞上有血管细胞粘附分子－1及内皮细胞白细胞粘附分子－1的表达，且其表达量均随时间增多。提示内皮细胞粘附分子的表达增加可能是脂质过氧化损伤导致单核细胞粘附增多的重要机制。
To observe the effect of lipid peroxidation injury on the expression of cell adhesion molecules, the lipid peroxidation of cultured human vascular endothelial cells induced by hydrazine was measured and its content of MDA and monocyte adhesion rate were detected. Microscopic observation of cell adhesion molecule expression. The results showed that compared with the control group, the content of malondialdehyde in endothelial cells was increased, the adhesion rate of monocytes was significantly increased (P <0.01), the adhesion of vascular endothelial cells to endothelial cells and endothelial cell leukocyte adhesion Molecule-1 expression, and its expression increased over time. Suggesting that increased expression of endothelial cell adhesion molecules may be lipid peroxidation damage leading to monocyte adhesion is an important mechanism.