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在鼠疟模型上观察了维生素E对青蒿琥酯抗疟作用的影响。小鼠口服维生素E后,在血清维生素E水平明显升高的情况下腹腔接种伯氏疟原虫,感染鼠用青蒿琥酯或氯喹治疗。结果发现,小鼠补充维生素E后,青蒿琥酯的抗疟作用减弱,氯喹的抗疟作用与维生素E无关。流式细胞仪的测定结果表明,青蒿琥酯可抑制疟原虫DNA的合成,而补充维生素E后这种作用减弱。可见宿主体内维生素E的水平可影响青蒿琥酯的抗疟作用。
The effects of vitamin E on the anti-malarial effect of artesunate were observed in a murine malaria model. After oral administration of vitamin E in mice, Plasmodium berghei were inoculated intraperitoneally with a significant increase in serum vitamin E levels, and the infected mice were treated with artesunate or chloroquine. The results showed that, after vitamin E supplementation in mice, artesunate antimalarial effect weakened, chloroquine antimalarial activity and vitamin E has nothing to do. Flow cytometry results show that artesunate can inhibit the synthesis of DNA of Plasmodium, and vitamin E supplementation after this effect weakened. It can be seen that the level of vitamin E in the host body can affect the anti-malarial effect of artesunate.