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该实验用12 5I标记磁性白蛋白纳米粒 ,经荷肝癌鼠的肝动脉、门静脉及颈静脉三种不同途径给药 ,旨在比较外置定位磁场与否 ,各组的肝癌区 (磁靶区 )、正常肝和肺组织的克组织放射性量以及肝癌区血管栓塞程度 ,以探求一种较佳的给药途径和方法。结果显示 :外置磁场能使磁性白蛋白纳米粒在靶区定位聚集 ,并减少其在非靶区的分布 ;外置磁场下经肝动脉给药组的肝癌组织区克组织放射量最高 (P <0 .0 1) ,而其正常肝和肺组织的克组织放射量最低 (P <0 .0 1) ,其肝癌区血管栓塞程度也明显高于经门静脉及经颈静脉组。表明 :外置定位磁场下经动脉途径注入磁性白蛋白纳米粒的磁靶向化疗栓塞效果最好。
In this experiment, 125I-labeled magnetic albumin nanoparticles were administered via hepatic artery, portal vein, and jugular vein of liver cancer-bearing mice in three different ways, aiming to compare whether the externally positioned magnetic field or not, the liver cancer area of each group (magnetic target area). ), the amount of Gram-negative radioactivity in normal liver and lung tissue, and the degree of vascular embolization in the liver cancer area to explore a better route and method of administration. The results showed that external magnetic field could locate and accumulate the magnetic albumin nanoparticles in the target area, and reduce its distribution in non-target areas; under the external magnetic field, the hepatic tissue in the hepatic artery administration group had the highest radiation dose (P<0.05). <0. 0 1), while the normal liver and lung tissues had the lowest dose of Gram-negative tissue (P <0. 01), and the degree of vascular embolization in the hepatic area was also significantly higher than that in the portal vein and transjugular vein group. The results showed that the magnetic targeting chemoembolization with magnetic albumin nanoparticle injection via the arterial route under the external positioning magnetic field had the best effect.