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目的研究细胞粘附分子CD15及Ki-67抗原在人脑胶质瘤中的表达及其临床意义。方法应用免疫组化S-P法检测例正常脑组织和858例人脑胶质瘤组织中CD15和Ki-67的表达。结果CD15和Ki-67在正常脑组织中均不表达,而在各级别的人脑胶质瘤中均有表达差异极显著,(P<0.01)。CD15和Ki-67的表达在高级别胶质瘤中均显著高于低级别胶质瘤(P<0.01),且CD15和Ki-67的表达呈显著正相关(P<0.05,r=0.462)。结论Ki-67可以作为评估胶质瘤细胞增殖的良好指标,CD15和Ki-67的表达可为判断胶质瘤的恶性程度和临床病理分级提供有意义的依据。
Objective To study the expression of CD15 and Ki-67 antigen in human glioma and its clinical significance. Methods The expression of CD15 and Ki-67 in normal brain tissue and 858 human glioma tissues were detected by immunohistochemical S-P method. Results CD15 and Ki-67 were not expressed in normal brain tissue, but there was significant difference in all grades of human glioma (P <0.01). The expression of CD15 and Ki-67 were significantly higher in high-grade gliomas than in low-grade gliomas (P <0.01), and there was a significant positive correlation between the expressions of CD15 and Ki-67 (P <0.05, r = 0.462) . Conclusion Ki-67 can be used as a good indicator to evaluate the proliferation of glioma cells. The expression of CD15 and Ki-67 may provide a basis for judging the malignant degree and clinicopathological grade of glioma.