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人红细胞生成素受体（ｈＥＰＯＲ）是位于相对成熟阶段人体红系祖细胞表面的跨膜蛋白，它能专一性结合人红细胞生成素（ｈＥＰＯ），将促进细胞生长、增殖和分化的信号传导到膜内，该过程涉及了ｈＥＰＯＲ自身及部分相关蛋白的磷酸化．ｈＥＰＯＲ具有一些与其功能相关的保守结构，它的氨基酸序列与鼠ＥＰＯＲ（ｍＥＰＯＰ）高度同源．ＥＰＯＲ因为膜外Ｒ１２９Ｃ突变或结合特定蛋白质而具有组成型活性．ＥＰＯＲ还与红白血病等多种血液病密切相关．
Human erythropoietin receptor (hEPOR) is a transmembrane protein located on the surface of human erythroid progenitor cells at a relatively mature stage. It can specifically bind to human erythropoietin (hEPO), and promote signal transduction of cell growth, proliferation and differentiation Into the membrane, the process involves the phosphorylation of hEPOR itself and some related proteins. hEPOR has some conserved structure associated with its function. Its amino acid sequence is highly homologous to murine EPOR (mEPOP). EPOR has constitutive activity due to extracellular R129C mutations or binding to specific proteins. EPOR is also closely associated with a variety of blood diseases such as erythroleukemia.