现用的钩端螺旋体(简称钩体)全菌体菌苗预防钩体病已有显著的预防效果,但因接种剂量大、针次多、人群不易接受、给预防工作带来了一定的困难。为此,于1978年～1984年我们所与浙江医科大学和浙江省卫生防疫站共同协作,先后完成了钩体外膜菌苗实验室小量研制与人体试验观察,结果证实外膜苗既有良好的免疫效果,又有使用方便等优点。然而上述研制只限于 The existing Leptospira (referred to as leptospirosis) whole bacterium vaccine for the prevention of leptospirosis has a significant preventive effect, but because of the vaccination dose, needle times, the crowd is not easy to accept, to prevent some of the difficulties . To this end, from 1978 to 1984, we collaborate with Zhejiang Medical University and Zhejiang Provincial Health and Epidemic Prevention Station, has completed a small amount of leptospiral bacterial vaccine laboratory research and human test results confirmed that the outer membrane seedlings both good The immune effect, but also easy to use and so on. However, the above research is limited to