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急性心肌梗塞(AMI)患者广泛心肌梗塞是目前常见的死因,大块心肌缺血可致泵衰竭和严重心律失常。从根本上缩小进展中大块心肌梗塞的范围,目前认为最好是早期恢复闭塞冠状动脉的血流。溶栓剂能溶解血栓内纤维蛋白凝块,消耗凝血第Ⅴ、Ⅶ因子、凝血酶原和纤维蛋白原,从而溶解血栓,使阻塞血管再灌注。治疗方法及疗效链激酶(SK):欧美大多采用,为β—链球菌的代谢产物,故有弱抗原性。1.冠状动脉内给药Rentrop 等在冠状动脉造影后注入硝酸甘油0.1～0.4mg,静注强的松龙250～1000mg 等,然后在冠状动脉开口处注入SK1～2万u(溶于5ml 生理盐水中),续以25万u(溶于1000ml 生理盐水中)按1000～2000u/min速度滴注15～60min,结束时静注肝索等。Leiboff
Acute myocardial infarction (AMI) patients with extensive myocardial infarction is the common cause of death, massive myocardial ischemia can cause pump failure and severe arrhythmia. Radically narrow the scope of progress in large myocardial infarction, it is currently considered the best early recovery of occluded coronary artery blood flow. Thrombolytic agents can dissolve thrombus fibrin clot, consumption of coagulation factor â ... ¢, â ... ¡factors, prothrombin and fibrinogen, which dissolve thrombus, blocking blood vessel reperfusion. Treatment methods and efficacy Streptokinase (SK): Mostly used in Europe and the United States, for the β-Streptococcus metabolites, it is weak antigenic. 1. Intravenous administration Rentrop et al in the coronary angiography after injection of nitroglycerin 0.1 ~ 0.4mg, intravenous prednisolone 250 ~ 1000mg, etc., and then injected into the coronary artery opening SK1 ~ 20000 u (dissolved in 5ml of physiology Saline), continued to 250000 u (dissolved in 1000ml saline) by 1000 ~ 2000u / min speed infusion 15 ~ 60min, the end of intravenous injection of hepatic cord and so on. Leiboff