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目的:探讨经鼻持续气道内正压通气(CPAP)治疗阻塞性睡眠呼吸暂停综合征(OSAS)的疗效,对1996～1999年在家坚持长期应用CPAP治疗的18例重度OSAS(有完善多导睡眠图(PSG)监测记录)患者进行对比分析。结果:(1)应用CPAP治疗后,OSAS症状消除。(2)13例(72%)患者复查PSG参数明显改善,18例停用CPAP治疗后PSG复查,最长呼吸暂停时间从66±21s缩短至43±24s(P<005);呼吸紊乱指数(AHI)从66±16降至28±20(P<0001);最低血氧饱和度(SaO2)从53%±19%提高至75%±11%(P<0.001)。(3)治疗前后18例患者体重、血压改变不明显,12例合并高血压的患者6例(50%)血压恢复到正常范围。结论:CPAP治疗OSAS有效,长期坚持治疗呼吸暂停引起的低氧血症,最长呼吸暂停时间改善,临床症状减轻或消失。其机制可能与患者呼吸调节功能改善有关
Objective: To investigate the efficacy of nasal continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea syndrome (OSAS). From 1996 to 1999, 18 patients with severe OSAS who had long-term use of CPAP at home (with complete polysomnography Figure (PSG) monitoring records) patients for comparative analysis. Results: (1) After treatment with CPAP, symptoms of OSAS were eliminated. (2) The PSG parameters were significantly improved in 13 patients (72%) and PSG in 18 patients with CPAP. The longest apnea time was shortened from 66 ± 21s to 43 ± 24s (P <005), and the index of respiratory disorder AHI) decreased from 66 ± 16 to 28 ± 20 (P <0.001). The minimum oxygen saturation (SaO2) increased from 53% ± 19% to 75% ± 11% (P <0.001). (3) Before and after treatment, the body weight and blood pressure of 18 patients did not change obviously. Among the 12 patients with hypertension, 6 patients (50%) returned to normal range. CONCLUSION: CPAP is effective in treating OSAS. It persists in treating hypoxemia caused by apnea for a long time, and the longest apnea time is improved and clinical symptoms are reduced or disappeared. The mechanism may be related to the improvement of respiratory function in patients