最近发现鸦片样物质(如脑啡肽和内啡肽等)不仅存在于脑内还广泛地存在于胃肠道内。Polak等用放射免疫测定法证明,人胰腺内也含有脑啡肽样免疫活性物。张万琴等还观察到豚鼠胆囊和总胆管有鸦片受体。正常机体内既然存在鸦片受体,必然与其自然的配基(包括内源性或外源性鸦片样物质)相结合,使受体所在的靶器官的活动发生改变。已知鸦片样物质与脑内鸦片受体结合后产生镇痛作用。但是鸦片样物质与胰内鸦片受体结合后对胰外分泌产生什么作用则报导得很少。Laffe曾总结了吗啡的 It has recently been found that opioids (such as enkephalins and endorphins, etc.) are found not only in the brain but also widely in the gastrointestinal tract. Polak et al. Demonstrated by radioimmunoassay that enkephalin-like immunoreactive was also contained in human pancreas. Zhang Wanqin also observed guinea pig gallbladder and the common bile duct opioid receptors. Since normal opioid receptors exist in the body, bound to its natural ligand (including endogenous or exogenous opioid substances), so that the target organ where the receptor activity changes. It is known that the opioid has an analgesic effect when it is combined with the opiate receptor in the brain. However, the effect of opioid binding to pancreatic opioid receptors on pancreatic exocrine production is poorly reported. Laffe has summarized morphine