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1973年1月至1986 年6 月共收治行首次根治性放疗的鼻咽癌562 例。全部病人随访10年以上。全组总的10 年生存率30.8% (173/562)。Ⅰ~Ⅳ期分别为64.3% (9/14)、45.5% (56/123)、30.4% (73/240) 和18.9% (35/185), Ⅰ、Ⅱ期明显高于Ⅲ、Ⅳ期 (P< 0.001)。10 年生存率局限于鼻咽腔为32.5% (152/468), 超腔22.3% (21/94) (P< 0.05)。有无颅神经受损的10 年生存率分别为34.4% 和20% (P< 0.01)。尤以前后组颅神经同时受损和颅神经受损伴颅底骨破坏者疗效最差。颈淋巴结转移情况亦与预后明显相关, 有否淋巴结转移、颈结的固定与否、单双侧、上或全颈以及锁骨上受累均有明显不同的预后,各组间的差异均有统计学意义。照射剂量对预后亦有明显的影响,原发灶剂量60~75Gy 组疗效明显好于其他组。主要死因是远处转移与局部复发。认为早期诊断与早期根治性放疗是提高生存率的关键, 放疗剂量以60~75Gy 为佳。
January 1973 to June 1986 received a total of 562 cases of nasopharyngeal carcinoma for the first time. All patients were followed for more than 10 years. The overall 10-year overall survival rate was 30.8% (173/562). The rates of stage Ⅰ ~ Ⅳ were 64.3% (9/14), 45.5% (56/123), 30.4% (73/240) and 18.9% (35/185), respectively Obviously higher than Ⅲ, Ⅳ (P <0.001). The 10-year survival rate was limited to 32.5% (152/468) in the nasopharynx and 22.3% (21/94) in the super-lumen (P <0.05). The 10-year survival rates with or without cranial nerve injury were 34.4% and 20%, respectively (P <0.01). Especially in the group before and after the cranial nerve damage and cranial nerve damage with skull base failure were the worst. Cervical lymph node metastasis was also significantly associated with the prognosis, whether lymph node metastasis, neck fixation or not, single or bilateral, or neck and supraclavicular involvement were significantly different prognosis, the differences between the groups were statistically significant significance. The radiation dose also had a significant effect on the prognosis. The efficacy of the primary tumor dose 60 ~ 75Gy group was significantly better than the other groups. The main cause of death is distant metastasis and local recurrence. That the early diagnosis and early radical radiotherapy is the key to improve the survival rate, radiotherapy dose to 60 ~ 75Gy better.