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目的观察特布他林联合布地奈德雾化吸入治疗支气管哮喘的临床效果。方法选取医院呼吸内科收治的支气管哮喘患者78例,随机分为单一组和联合组,每组39例。单一组单纯应用布地奈德雾化吸入治疗,联合组应用特布他林+布地奈德雾化吸入治疗。观察并记录2组患者咳嗽、气促、哮鸣音等症状体征消失时间;治疗前后肺功能相关指标改善情况,如一秒钟用力呼气量(FEV_1)、用力肺活量(FVC)、呼气峰值流速(PEF);用药治疗期间观察2组药物不良反应发生情况。结果经观察发现,联合组咳嗽、气促、哮鸣音、呼吸困难等症状体征消失时间均明显短于单一组(P<0.01);治疗后,联合组FEV_1、FVC、PEF值均显著优于单一组(P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论与单一用药相比,联合应用特布他林和布地奈德雾化吸入治疗支气管哮喘患者效果更佳,能够快速而有效改善临床症状体征,且安全性高。
Objective To observe the clinical efficacy of terbutaline combined with budesonide inhalation in the treatment of bronchial asthma. Methods A total of 78 patients with bronchial asthma were enrolled in the Department of Respiratory Medicine, which were randomly divided into single group and combined group, with 39 cases in each group. A single group was treated with inhaled budesonide alone and a combination of terbutaline and budesonide inhaled. The signs and symptoms of cough, shortness of breath and wheeze were observed and recorded in two groups. The improvement of pulmonary function before and after treatment such as forced expiratory volume per second (FEV_1), forced vital capacity (FVC), peak expiratory flow rate (PEF); observed during the treatment of adverse drug reactions in two groups. Results After the observation, the disappearance time of cough, shortness of breath, wheeze and dyspnea in the combined group were significantly shorter than those in the single group (P <0.01). After treatment, FEV_1, FVC and PEF in the combined group were significantly better than those in the single group Single group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Compared with single drug, the combination of terbutaline and budesonide atomized inhalation in patients with bronchial asthma better effect, can quickly and effectively improve the clinical symptoms and signs, and high safety.