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茶碱不仅具有扩张支气管作用。同时还有刺激呼吸中枢,增加膈肌收缩力和抗炎作用。几十年来一直广泛用于治疗哮喘和慢性阻塞性肺疾病(COPD)患者。本文作者研究了长期茶碱治疗对同时接受多种支气管扩张剂治疗的严重COPD患者静息、运动及睡眠时肺功能和气体交换的影响。 方法 采用随机、双盲、对照、交叉的方法,对10例处于稳定期的严重COPD患者(平均FEV_1占预
Theophylline not only has the role of expanding bronchus. Also stimulate the respiratory center, increased diaphragmatic contractility and anti-inflammatory effect. Has been widely used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) patients for decades. The authors studied the effects of long-term theophylline therapy on resting lung function and gas exchange during rest, exercise and sleep in patients with severe COPD who received multiple bronchodilators simultaneously. Methods A randomized, double-blind, controlled and crossover study was conducted in 10 patients with severe COPD in stable phase (mean FEV 1 preeclampsia