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多囊卵巢综合征（ PCOS）是一种复杂的生殖内分泌疾病，主要特征为月经稀发或闭经、高雄激素血症、卵巢多囊样改变以及代谢紊乱。其中，胰岛素抵抗在PCOS患者中很常见。高糖通过糖类反应元件增加了血清硫氧还蛋白相互作用蛋白（ TXNIP）的表达，导致胰岛素抵抗，从而加强了氧化应激，引起β细胞凋亡。由于 PCOS 妇女血清 TXNIP 水平较正常妇女明显偏高，因此通过探究TXNIP 与PCOS的相关性，可以为寻找PCOS代谢紊乱治疗靶点提供新的依据与线索。“,”Polycystic ovary syndrome(PCOS) is a complex reproductive endocrine disease,and its main characteristics are oligomenorrhea or amenorrhea,hyperandrogenemia,polycystic ovary change,and metabolic disorders,particularly that insulin resistance is common in PCOS patients.Hyperglycemia increases the expression of serum thioredoxin-interacting protein ( TXNIP) with carbohydrate response element,which cau-ses insulin resistance and βcell apoptosis by enhancing the oxidative stress.Serum thioredoxin-interacting protein levels of PCOS women are significantly higher than the normal women.By exploring the relationship between TXNIP and PCOS correlation,the new evidence and clues for the treatment of PCOS metabolic disor-der will be found.