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目的探讨新生儿心肺复苏时肾上腺素的最佳用药浓度及剂量。方法将 75例新生儿复苏病例 ,按肾上腺素静注的不同用药浓度和剂量分为 A、B、C 3组。A组用 1∶ 10 0 0浓度肾上腺素 0 .0 1～ 0 .0 3 mg/kg;B组用 1∶ 10 0 0浓度 0 .1～ 0 .2 mg/kg;C组用 1∶ 10 0 0 0浓度 0 .0 1mg/kg。结果 A组和 B组肾上腺素首剂有效率均明显高于 C组 (P<0 .0 5 ) ,而在 A、B两组间无统计学差异 (P>0 .0 5 )。短期存活率 A、B两组也明显高于 C组 (P<0 .0 5 )。长期存活率 A组明显高于 C组 (P<0 .0 5 ) ,B组和 C组无统计学差异 (P>0 .0 5 )。结论新生儿复苏时肾上腺素的最佳浓度是 1∶ 10 0 0 ,剂量是 0 .0 1～ 0 .0 3 mg/kg。
Objective To investigate the best dosage and dosage of epinephrine in neonatal cardiopulmonary resuscitation. Methods A total of 75 cases of neonatal resuscitation were divided into groups A, B and C according to different concentrations and doses of epinephrine intravenous injection. A group with 1: 100 concentrations of epinephrine 0 .0 1 ~ 0. 3 mg / kg; B group with 1: 100-0.1 ~ 0.2 mg / kg; C group with 1:10 0 0 0 concentration 0 .0 1mg / kg. Results The effective rates of the first dose of adrenaline in group A and group B were significantly higher than those in group C (P <0.05), but not in group A and B (P> 0.05). The short-term survival rates in groups A and B were also significantly higher than those in group C (P <0.05). The long-term survival rate in group A was significantly higher than that in group C (P <0.05). There was no significant difference between group B and C (P> 0.05). Conclusion The best concentration of epinephrine in neonatal resuscitation is 1:10 0 and the dose is 0.001-0.03 mg / kg.