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目的 研究胃癌组织中P15蛋白和血管内皮生长因子 (VEGF)的表达及相关性。方法 应用SP免疫组织化学方法检测了 16 0例胃癌和 5 2例胃良性病变中P15蛋白和VEGF的表达情况。结果 P15蛋白在胃癌中阳性率为 43 8% (70 /16 0例 ) ,在胃良性病变中的阳性率为 6 9 2 % (36 /5 2例 ) (P <0 0 5 )。VEGF在胃癌中的阳性表达率为 75 0 % (12 0 /16 0例 ) ,在胃良性病变中的阳性表达率为 7 7% (4/5 2例 ) (P <0 0 0 1)。P15蛋白阳性 /VEGF阴性表达率于胃癌中为 11 3% (18/16 0例 ) ,胃良性病变中为 6 9 2 % (36 /5 2例 ) (P <0 0 0 1) ;P15蛋白阴性 /VEGF阳性表达率于胃癌中为 42 5 % (6 8/16 0例 ) ,胃良性病变中为 7 7% (4/5 2例 ) (P <0 0 0 1)。结论 胃癌中存在P15蛋白下调和VEGF上调 ,且两者具有相关性。
Objective To study the expression and correlation of P15 protein and vascular endothelial growth factor (VEGF) in gastric cancer. Methods SP immunohistochemistry was used to detect the expression of P15 protein and VEGF in 160 gastric cancer and 52 gastric benign lesions. Results The positive rate of P15 protein in gastric cancer was 43.8% (70/160 cases), and the positive rate of P15 protein in gastric benign lesions was 69.2% (36/52 cases) (P <0.05). The positive expression rate of VEGF in gastric cancer was 75 0% (12 0/160), and the positive expression rate of VEGF in gastric benign lesions was 77% (4/5 2 cases) (P 0 01). P15 protein positive / VEGF negative expression rate in gastric cancer was 11 3% (18/16 0 cases), gastric benign lesions was 69.2% (36/5 2 cases) (P <0 01); P15 protein Negative / VEGF positive rates were 42.5% (68/160) in gastric cancer and 77% (4/5 2) in gastric benign lesions (P <0.01). Conclusion There is a correlation between P15 protein downregulation and VEGF upregulation in gastric cancer.