采用反相高效液相色谱外标法测定人血清中伪麻黄碱浓度，并测定８例志愿受试者伪麻黄碱血药浓度，并计算分析药物动力学参数，结果单剂量口服９０ｍｇ盐酸伪麻黄碱后，药时曲线呈一室模型。Ｔｍａｘ＝１．７±１．１ｈ，Ｃｍａｘ＝３６４±９４ｎｇ·ｍｌ－１，ＡＵＣ（０～∞）＝２６６２±３０３（ｎｇ·ｈ·ｍｌ－１），Ｔ１／２＝４．０±１．０ｈ，Ｋａ＝２．４±１．４ｈ－１，Ｋｅ＝０．１９±０．０４ｈ－１，Ｖｄ＝０．１９±０．０５ｍｇ，Ｃｌ＝０．０３±０．０１ｍｇ·ｈ－１。 The RP-HPLC method was used to determine the concentration of pseudoephedrine in human serum. The plasma concentrations of pseudoephedrine in eight volunteers were determined and the pharmacokinetic parameters were calculated. Results After the single oral dose of 90mg pseudoephedrine hydrochloride, A room model. Tmax = 1.7 ± 1.1 h, Cmax = 364 ± 94 ng · ml -1, AUC (0 to ∞) = 2662 ± 303 (ng · h · ml -1), and T1 / 2 = 4.0 ± 1. 0h, Ka = 2.4 ± 1.4h-1, Ke = 0.19 ± 0.04h-1, Vd = 0.19 ± 0.05mg, Cl = 0.03 ± 0.01mg · h-1.