原发性干燥综合征 (PSS)是临床上引起低钾无力的常见原因 ,其低钾常由并发的肾小管酸中毒引起。但临床医生由于对PSS缺乏认识 ,以致误诊率相当高。本文报道以低钾无力为首发表现的 5例PSS并Ⅰ型肾小管酸中毒的临床误诊分析 ,以期提高对该病的认识和早期诊断水平。1　资料与方法 Primary Sjogren’s Syndrome (PSS) is a common cause of clinical hypokalemia and hypokalemia is often caused by concurrent renal tubular acidosis. However, due to the lack of understanding of PSS, clinicians have a very high rate of misdiagnosis. This article reports the clinical manifestations of 5 cases of PSS and type Ⅰ renal tubular acidosis with hypokalemia as the first manifestation, in order to improve the understanding and early diagnosis of the disease. 1 data and methods