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目的：观察蚓激酶对突发性聋的疗效及血液流变学变化。方法：应用蚓激酶６０ｍｇ，ｐｏ，ｔｉｄ，治疗突发性聋４５例５０耳（男性２８例，女性１７例；年龄４３±ｓ１２ａ），并与３０例３４耳（男性１７例，女性１３例；年龄４２±１２ａ）用尿激酶４万Ｕ，加入１０％右旋糖酐－４０５００ｍＬ中静脉滴注治疗，ｑｄ，作对照，疗程均为３ｗｋ。结果：２组总有效率分别为８０％和５３％，蚓激酶疗效优于尿激酶（Ｐ＜０．０５）。血液流变学证实，蚓激酶有明显降低病人的血液粘度作用（Ｐ＜０．０５，０．０１）。结论：蚓激酶治疗突发性聋疗效可靠。
Objective: To observe the effect of lumbrokinase on sudden deafness and hemorheological changes. Methods: Fifty-five ears (28 males, 17 females and 43 ± s12a) of sudden deafness were treated with lumbrokinase 60 mg, po, tid and 30 cases of 34 ears (17 males and 13 females; Age 42 ± 12a) with urokinase 40,000 U, add 10% dextran -40500mL intravenous infusion, qd, control, treatment were 3wk. Results: The total effective rates of two groups were 80% and 53%, respectively. The efficacy of lumbrokinase was better than that of urokinase (P <0.05). Hemorheology confirmed that lumbrokinase significantly reduced the patient’s blood viscosity (P <0.05, 0.01). Conclusion: Lumbrokinase is effective in treating sudden deafness.