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目的探讨酒石酸美托洛尔对慢性心力衰竭患者心功能及血浆脑钠肽水平的影响。方法运用随机抽样法收集2012年3月至2014年3月在本院进行治疗的慢性心力衰竭80例患者资料,均采用常规治疗方法,给予治疗,疗程为6个月,观察并比较患者治疗前后的心功能及血浆脑钠肽水平。结果经患者治疗前后总胆固醇、甘油三酯测定结果比较,无明显变化,低密度脂蛋白胆固醇虽然有所下降,但下降程度并不明显,各项指标与治疗前比较差异均无统计学意义(均P>0.05);治疗前后比较,患者的左心室后壁厚度(LVPWT)、室间隔厚度(IVST)、左心室收缩末期内径(LVEDs)以及左心室舒张末期内径(LVEDd)均无明显变化,而血浆脑钠肽水平明显下降,射血分数(EF)明显上升,差异有统计学意义(P<0.05);治疗后与治疗前比较,患者的心功能分级明显改善(P<0.05)。结论酒石酸美托洛尔应用于慢性心力衰竭患者的治疗中,能有效改善其心超指标和血浆脑钠肽水平,且不会影响患者的肝肾功能,具有安全性和有效性。
Objective To investigate the effects of metoprolol tartrate on cardiac function and plasma brain natriuretic peptide in patients with chronic heart failure. Methods The data of 80 patients with chronic heart failure who were treated in our hospital from March 2012 to March 2014 were collected by random sampling method. All the patients were treated by conventional method. The course of treatment was 6 months. Before and after treatment, Heart function and plasma brain natriuretic peptide levels. Results Before and after treatment, the results of total cholesterol and triglyceride did not show any significant change. Although LDL cholesterol decreased, the extent of decrease was not obvious, and there was no significant difference between the indexes before and after treatment (P < (P> 0.05). LVPWT, IVST, LVEDs and LVEDd in patients before and after treatment did not change significantly, However, the level of plasma brain natriuretic peptide decreased significantly and the ejection fraction (EF) increased significantly (P <0.05). After treatment, the patients’ cardiac function scores improved significantly (P <0.05). Conclusion Metoprolol tartrate can be used in the treatment of patients with chronic heart failure, which can effectively improve its cardiac index and plasma brain natriuretic peptide levels, and will not affect the patient’s liver and kidney function. It is safe and effective.