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目的观察糖皮质激素治疗重症甲型H1N1流行性感冒(流感)的临床疗效。方法 26例重症甲型H1N1流感患者,随机分为对照组和研究组,各13例。对照组行常规治疗,研究组在对照组基础上给予糖皮质激素治疗,对比两组患者的临床疗效。结果研究组的退热时间、肺部炎症吸收时间均短于对照组(P<0.05);研究组病死率高于对照组,但差异无统计学意义(P>0.05)。结论重症甲型H1N1流感行糖皮质激素治疗,改善了患者的生存质量,但同时应特别注意可能引起的不良反应。
Objective To observe the clinical efficacy of glucocorticoid in the treatment of severe type A (H1N1) influenza (influenza). Methods Twenty-six patients with severe H1N1 influenza were randomly divided into control group and study group, with 13 cases in each group. The control group received routine treatment. The study group was given glucocorticoid on the basis of the control group, and the clinical efficacy was compared between the two groups. Results The antipyretic time and pulmonary inflammatory absorption time in the study group were shorter than those in the control group (P <0.05). The mortality rate in the study group was higher than that in the control group, but the difference was not statistically significant (P> 0.05). Conclusions Glucocorticoid treatment of severe type A H1N1 influenza improves the quality of life of patients, but special attention should be paid to the possible adverse reactions.