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激烈的市场竞争,使得经典方剂二次开发,尤其是针对已有中成药进行的二次开发,成为许多制药企业研发重点。在经典方的二次开发中,药物代谢动力学将成为一个重要的手段。目前我国对经典方的药动学研究主要集中在解释方剂配伍的合理性,以及指导临床用药这两方面上,较少的以此为突破口进行经典方的二次开发。尝试从中药、天然药物新药分类的角度,浅析药动学在经典方二次开发中的应用,以探寻可以申报新药的可能性。
Intense market competition, making the secondary development of the classic prescription, especially for secondary development of existing proprietary Chinese medicines, has become the focus of many pharmaceutical companies R & D. In the secondary development of the classic side, pharmacokinetics will become an important means. At present, the pharmacokinetics of classic prescriptions in our country mainly focuses on the rationality of compatibility of prescriptions and the guidance of clinical medication. From the perspective of the classification of new drugs of traditional Chinese medicine and natural medicine, the application of pharmacokinetics in the secondary development of classical prescriptions is attempted to explore the possibility of declaring new drugs.