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目的:分析奥沙利铂联合卡培他滨对晚期结肠癌的治疗效果及毒副反应。方法:将76例晚期结肠癌患者随机分为两组各38例,对照组行顺铂、5氟尿嘧啶联合亚叶酸钙治疗,观察组给予奥沙利铂联合卡培他滨治疗,比较两组治疗情况。结果:观察组治疗总有效率84.2%明显高于对照组的63.2%(P<0.05),毒副作用发生率31.6%明显低于对照组的60.5%(P<0.05)。结论:奥沙利铂联合卡培他滨对晚期结肠癌效果显著,且用药安全性高,值得推广。
Objective: To analyze the curative effect and toxicity of oxaliplatin combined with capecitabine on advanced colon cancer. Methods: 76 patients with advanced colon cancer were randomly divided into two groups of 38 patients. The control group was treated with cisplatin and 5-fluorouracil combined with leucovorin. The observation group was given oxaliplatin combined with capecitabine. Happening. Results: The total effective rate in observation group was significantly higher than that in control group (84.2% vs 63.2%, P <0.05). The incidence of toxic and side effects was significantly lower than that in control group (31.6% vs. 60.5%, P <0.05). Conclusion: The combination of oxaliplatin and capecitabine has significant effect on advanced colon cancer and is safe to treat. It is worth to be popularized.