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目的对比替硝唑与甲硝唑治疗细菌性阴道病的临床疗效。方法将80例细菌性阴道病患者按照入院顺序随机分为观察组和对照组各40例。观察组采用替硝唑治疗,对照组采用甲硝唑治疗,比较2组患者药物消除半衰期、临床疗效和不良反应情况。结果观察组药物消除半衰期为(14.79±0.56)h长于对照组的(9.54±0.45)h,总有效率为87.5%高于对照组的62.5%,不良反应发生率为2.5%低于对照组的12.5%,差异均有统计学意义(P<0.05)。结论相较于甲硝唑,替硝唑治疗细菌性阴道病的临床治疗效果更为突出,药物消除半衰期更长,不良反应发生率较低,建议在临床治疗中广泛应用。
Objective To compare the clinical efficacy of tinidazole and metronidazole in the treatment of bacterial vaginosis. Methods Eighty patients with bacterial vaginosis were randomly divided into observation group and control group according to the admission order of 40 cases. The observation group was treated with tinidazole and the control group was treated with metronidazole. The elimination half-life, clinical efficacy and adverse reactions of the two groups were compared. Results The elimination half-life of the observation group was (14.79 ± 0.56) h longer than that of the control group (9.54 ± 0.45) h, the total effective rate was 87.5% higher than 62.5% of the control group, and the adverse reaction rate was 2.5% lower than that of the control group 12.5%, the differences were statistically significant (P <0.05). Conclusion Compared with metronidazole, tinidazole treatment of bacterial vaginosis clinical treatment is more prominent, longer half-life of drug elimination, the incidence of adverse reactions is low, it is recommended in clinical treatment widely used.