目前对苯妥英(Phenytoin PHT)作用机制已进行广泛、深入的研究,其主要作用是对人体及动物的单个细胞、细胞群及各系统生物电活动具有调节功能。它可抑制或消除神经和肌肉细胞的异常电活动,而对正常生物电的产生和传导无影响。该特性的电生理基础在于它对钠、钾、钙的跨膜运动和在细胞内分布具有调节作用。最新研究表明,PHT可与激活状态的钠通道结合,调节钠内流。在神经突触处PHT可通过这一机制影响钙依赖性的多种神经递质的传递和突触后反 At present, the mechanism of Phenytoin PHT has been extensive and in-depth studied, and its main function is to regulate the bioelectric activities of individual cells, cell populations and various systems of human and animals. It can inhibit or eliminate the abnormal electrical activity of nerve and muscle cells, but has no effect on the generation and conduction of normal bioelectrical. The electrophysiological basis of this property lies in its regulation of transmembrane movement of sodium, potassium and calcium and its distribution within the cell. Recent research shows that PHT can bind to the activated sodium channel to regulate sodium influx. PHT at neuronal synapses can influence calcium-dependent delivery of multiple neurotransmitters and postsynaptic responses through this mechanism