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目的探讨抗结核药物性肝功能损害的病例特征和临床表现。方法收集410例结核病患者,分析患者发生抗结核药物性肝功能损害的临床特点及其相关因素。结果 410例结核病患者中,16.3%(67/410)发生肝功能损害,男性肝功能损害比例高于女性,差异有统计学意义(P<0.05);各年龄组间肝功能损害发生率比较差异无统计学意义(P>0.05);服药2个月内发生肝功能损害的患者比例高于服药>2个月的比例;肝功能损害无症状者占65.7%(44/67),具有发热和黄疸症状仅占4.5%。结论男性是肝功能损害的易患因素,尤其在治疗期的2个月内易发生;必须关注无症状肝功能损害病例,定期进行肝功能检测,并采取合适药物治疗措施,确保完成抗结核治疗疗程。
Objective To investigate the clinical features and clinical features of anti-TB drug-induced liver dysfunction. Methods 410 cases of tuberculosis patients were collected, and the clinical characteristics and related factors of anti-TB drug-induced liver dysfunction were analyzed. Results Among the 410 TB patients, 16.3% (67/410) had liver damage, and the proportion of male patients with liver dysfunction was higher than that of the female (P <0.05). The incidence of liver dysfunction among different age groups was significantly different (P> 0.05). The proportion of patients with liver dysfunction within 2 months of taking medicine was higher than the proportion of taking medicine for 2 months. Asymptomatic liver dysfunction accounted for 65.7% (44/67), with fever and Jaundice symptoms only accounted for 4.5%. Conclusion Male is a predisposing factor of liver dysfunction, especially in the treatment period of 2 months easy to occur; must pay attention to the case of asymptomatic liver dysfunction, regular liver function tests, and take appropriate drug treatment measures to ensure the completion of anti-TB treatment Course of treatment.