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目的 探索α2 受体拮抗剂咪唑克生能否增强 5 HT1A受体激动剂丁螺环酮的抗冲突作用。方法 采用焦虑动物模型Vogel冲突饮水实验。 结果 低于有效剂量的咪唑克生 (0 1～ 1 0mg·kg-1)当与低于有效剂量的丁螺环酮 (0 3mg·kg-1)合用后 ,以剂量依赖性的方式 ,明显增加丁螺环酮的冲突饮水次数 ,当与有效剂量的丁螺环酮 (1 0mg·kg-1)合用后 ,抗冲突饮水次数的改变率从单用时的 +10 9%增至合用时的 +140 %～ +5 85 %。同时 ,合用后对大鼠自发性饮水没有影响。结论 咪唑克生能增强丁螺环酮的抗冲突作用 ,提示去甲肾上腺能和 5 羟色胺能系统之间可能存在交互作用 ,共同调节冲突行为。
Objective To explore whether imidazocine, an α2-receptor antagonist, can enhance the anti-stroke effect of 5-HT1A receptor agonist buspirone. Methods The anxiety animal model Vogel conflict drinking water experiment. The results were lower than the effective dose of imidizumab (0 1 ~ 10mg · kg-1) and less than the effective dose of buspirone (0 3mg · kg-1) combined with a dose-dependent manner, significantly The increase in the number of times of buspirone conflict drinking, when combined with an effective dose of buspirone (10 mg · kg-1), the rate of change in the number of anti-contraindicated drinking increases from +10 9% at the time of single use to +140% ~ +5 85%. At the same time, spontaneous drinking water in rats has no effect. Conclusion Imidacloprid enhances the anti-conflict effect of buspirone, suggesting that there may exist interactions between noradrenaline and serotonergic system to regulate the conflict behavior.