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目的探究血清胱抑素C、前清蛋白的水平与老年2型糖尿病(T2DM)患者早期肾脏疾病的相关性。方法选取该院2012年2月至2014年1月确诊并收治的T2DM患者共130例,其中T2DM伴早期肾脏疾病者共70例,单纯T2DM患者60例,将其分为2组,通过实验室检查血清胱抑素C、前清蛋白的水平分析2项指标与T2DM患者早期肾脏疾病的相关性。结果 T2DM伴早期肾脏损伤者血清胱抑素C水平较单纯T2DM患者明显升高,其前清蛋白水平明显低于单纯T2DM患者,差异具有统计学意义(P<0.01)。结论血清胱抑素C、前清蛋白水平可以有助于监测和判断T2DM患者是否发生早期肾脏损伤,对T2DM伴肾脏损伤具有重要意义,具有较高临床价值,值得继续研究和应用。
Objective To investigate the correlation between serum cystatin C and prealbumin levels and early renal disease in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 130 T2DM patients diagnosed and treated from February 2012 to January 2014 in our hospital were selected. Among them, 70 cases of T2DM with early renal disease and 60 cases of simple T2DM were divided into two groups, Check serum cystatin C, prealbumin levels analysis of two indicators and T2DM patients with early renal disease. Results Serum levels of cystatin C in T2DM patients with early renal injury were significantly higher than those in T2DM patients. The level of serum albumin in T2DM patients with T2DM was significantly lower than that of T2DM patients (P <0.01). Conclusions Serum levels of cystatin C and prealbumin may be helpful for monitoring and judging whether early renal injury occurs in T2DM patients and is of great significance to T2DM with renal injury. It is of high clinical value and worth further research and application.