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目的比较单纯阿片药物治疗癌痛与姑息性化疗联合阿片药物治疗癌痛的临床效果。方法选取在我院接受治疗的58例经完整病理学或细胞学确诊并伴有癌痛的晚期胃癌患者作为观察对象，根据随机数字表法将观察对象分成两组进行临床止痛效果比较，每组均为29例。其中观察组接受姑息性化疗联合阿片药物治疗；对照组仅接受单纯阿片药物治疗，对两组临床治疗效果进行比较。结果治疗前，两组癌痛评分比较无统计学差异，>0.05；治疗后两组患者的癌痛评分均有所下降，<0.01；对比两组评分下降程度，观察组效果更佳，<0.01；观察组整体癌痛发作次数少于对照组，<0.01；对两组患者阿片药物使用量进行比较，观察组用药量明显少于对照组，0.05);after treatment,the score of cancer pain of two groups was slightly reduced ( <0.01);the score of cancer pain of observation group was lower than that of control group ( <0.01);the overal at ack frequency of cancer pain of observation group was fewer than that of control group ( <0.01);the dosage of Morphine Sulfate Sustained-release Tablets of observation group was significantly lower than that of control group ( <0.01).Conclusion The pal iative chemotherapy combined with opioid has an obvious ef ect in the control of cancer pain,can ef ectively reduce the score of cancer pain and the dosage of relevant drugs.