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[目的]观察黄芪桂枝五物汤联合甲钴胺治疗糖尿病周围神经病变疗效。[方法]使用随机平行对照方法,将86例住院及门诊患者按随机数字法分为两组。对照组43例甲钴胺片0.5mg/次,3次/d,口服。同时予以常规治疗,包括糖尿病常规健康教育、饮食控制、单用或者联合应用胰岛素及降糖药、运动治疗等,控制血糖处于正常水平。治疗组43例黄芪桂枝五物汤(黄芪30g,鸡血藤、花粉、丝瓜络、白芍各15g,红花、桃仁、桂枝、没药、乳香及牛膝各10g,生姜5g,甘草6g,大枣10枚)。1剂/d,浸泡30min,水煎120mL,2次/d。西药治疗同对照组。连续治疗28d为1疗程。观测临床症状、神经传导速度(腓总神经、腓肠神经)、不良反应。连续治疗4疗程,判定疗效。[结果]治疗组治愈21例,好转20例,无效2例,总有效率95.30%。对照组治愈15例,好转19例,无效9例,总有效率79.10%。治疗组疗效优于对照组(P<0.05)。神经传导速度两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]黄芪桂枝五物汤联合甲钴胺治疗糖尿病周围神经病变,效果显著,值得推广。
[Objective] To observe the therapeutic effect of Huangqi Guizhi Wuwu Decoction combined with mecobalamin on diabetic peripheral neuropathy. [Methods] Using randomized parallel method, 86 cases of inpatients and outpatients were divided into two groups according to random number method. Control group, 43 cases of methylcobalamin tablets 0.5mg / times, 3 times / d, orally. At the same time be routine treatment, including regular health education in diabetes, diet control, single or combined use of insulin and hypoglycemic agents, exercise therapy, control of blood glucose at normal levels. Treatment group, 43 cases of astragalus Guizhi five Wu Tang (Astragalus 30g, Millettia, pollen, loofah, peony root of 15g, safflower, peach kernel, cassia twig, myrrh, frankincense and Achyranthes each 10g, ginger 5g, 6g, jujube 10). 1 dose / d, soak 30min, decoction 120mL, 2 times / d. Western medicine treatment with the control group. Continuous treatment 28d for a course of treatment. Clinical symptoms, nerve conduction velocity (common peroneal nerve, sural nerve), adverse reactions were observed. Continuous treatment of 4 courses to determine the efficacy. [Results] The treatment group cured 21 cases, improved in 20 cases, 2 cases, the total effective rate was 95.30%. The control group was cured in 15 cases, improved in 19 cases, ineffective in 9 cases, the total effective rate was 79.10%. The treatment group was better than the control group (P <0.05). The nerve conduction velocity was improved in both groups (P <0.05), and the treatment group improved better than the control group (P <0.05). [Conclusion] Huangqi Guizhi Wuwu Decoction combined with mecobalamin in the treatment of diabetic peripheral neuropathy, the effect is significant, it is worth promoting.