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目的探讨厄贝沙坦治疗原发性高血压并早期肾损伤的临床疗效。方法选取广汉市第二人民医院2014年9月—2016年3月收治的原发性高血压并早期肾损伤患者70例,按照治疗方案不同将患者分为观察组与对照组,各35例。观察组予以厄贝沙坦治疗,对照组予以美托洛尔治疗,均持续治疗8周。比较两组患者治疗前后血压与尿微量蛋白(MAU)水平、肱动脉舒张功能。结果治疗前后两组患者收缩压、舒张压比较,差异无统计学意义(P>0.05)。治疗前两组患者MAU水平比较,差异无统计学意义(P>0.05);治疗后观察组MAU水平低于对照组(P<0.05)。治疗前两组患者反应性充血时、含硝酸甘油后内径舒张比较,差异无统计学意义(P>0.05);治疗后观察组患者反应性充血时内径舒张大于对照组(P<0.05);治疗后两组患者含硝酸甘油后内径舒张比较,差异无统计学意义(P>0.05)。结论厄贝沙坦治疗原发性高血压并早期肾损伤的临床疗效确切,可改善患者肾小球功能,降低血压,提高患者的生活质量。
Objective To investigate the clinical efficacy of irbesartan in the treatment of essential hypertension and early renal injury. Methods Seventy patients with primary hypertension and early renal injury who were treated in Guanghan No.2 People’s Hospital from September 2014 to March 2016 were selected and the patients were divided into observation group and control group with 35 cases in each group. The observation group was treated with irbesartan, while the control group was treated with metoprolol, all of which were treated for 8 weeks. Blood pressure and urinary microalbumin (MAU) levels and brachial artery diastolic function were compared between the two groups before and after treatment. Results Before and after treatment systolic blood pressure and diastolic blood pressure in both groups showed no significant difference (P> 0.05). There was no significant difference in MAU levels between the two groups before treatment (P> 0.05). After treatment, MAU level in the observation group was lower than that in the control group (P <0.05). There was no significant difference in diastolic diameter after treatment with nitroglycerin between the two groups before treatment (P> 0.05). After treatment, the diastolic diameter of inner diameter of reactive hyperemia group was higher than that of control group (P <0.05) After the two groups of patients with nitroglycerin diastolic diameter comparison, the difference was not statistically significant (P> 0.05). Conclusion Irbesartan treatment of essential hypertension and early renal injury clinical efficacy is exact, can improve glomerular function in patients with lower blood pressure and improve the quality of life of patients.