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目的研究脑梗死时血清同型半胱氨酸(HC)及维生素 B_(12)(VB_(12))的变化及意义。方法对100例急性脑梗死(ACI)患者治疗前采静脉血4 mL,并在治疗后第1,7,14,21天及3个月时采空腹静脉血4mL,采用高效液相色谱法测定血清 HC、VB_(12)。结果 ACI 患者发病后血清 HC 即明显升高、VB_(12)即明显降低。血清 HC 和VB12治疗后第1,7,14,21天时均高于正常,与正常人相比差异有显著性意义,P<0.01;各时间血清 HC 比较及各时间 VB_(12)比较,差异无显著性意义,P>0.05。结论 ACI 患者血清 HC 升高、VB_(12)降低,说明高 HC 血症、低VB_(12)血症是缺血性卒中的危险因素,应采取防治措施。
Objective To study the changes and significance of serum homocysteine (HC) and vitamin B 12 (VB 12) in patients with cerebral infarction. Methods 100 mL of acute cerebral infarction (ACI) patients received 4 mL of venous blood before treatment and 4 mL of fasting venous blood was collected on days 1, 7, 14, 21 and 3 months after treatment. The plasma samples were collected by high performance liquid chromatography Serum HC, VB_ (12). Results Serum HC was significantly increased in patients with ACI and VB (12) was significantly decreased. Serum HC and VB12 were higher than normal on the 1st, 14th, 21st and 21st days after treatment, the difference was significant compared with the normal people, P <0.01; serum HC at different time and VB_ (12) No significant significance, P> 0.05. Conclusions Serum HC increased and VB_ (12) decreased in ACI patients, indicating that hypercholesterolemia and low VB_ (12) hyperlipidemia are risk factors for ischemic stroke. Prevention and treatment measures should be taken.