老年慢性病毒性肝炎凝血与血小板功能变化

来源 :苏州医学院学报 | 被引量 : 0次 | 上传用户:kenapple1368
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同步检测 190例老年慢性病毒性肝炎患者凝血酶元时间 (PT)、白陶土部分凝血活酶时间 (KPTT)、凝血酶元活动度 (ALT)、纤维蛋白原 (FIB)等 4项凝血指标和血小板计数 (PLT)、平均血小板体积 (MPV)、血小板分布宽度 (PDW)、血小板压积 (PCT)等 4项血小板参数。结果 :各型肝炎组与正常组比较 ,4项凝血指标有显著差异(P <0 .0 1) ,重型肝炎组PT和KPTT较其他肝炎组显著延长 (P <0 .0 1) ,FIB降低肝硬化组最显著 (P <0 .0 1) ;4项血小板指标有极显著差异 (P <0 .0 0 1) ,PLT和PCT减少肝硬化组最显著 (P <0 .0 1)。提示老年慢性病毒性肝炎可出现凝血障碍和血小板参数变化 ,各项检测的联合应用及动态观察 ,对评估肝损害的严重程度有重要意义 Synchronous detection of 190 cases of chronic viral hepatitis in patients with thrombin time (PT), kaolin clay partial thromboplastin time (KPTT), thrombin activity (ALT), fibrinogen (FIB) and other four indicators of coagulation and platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW), platelet pressure (PCT) and other four platelet parameters. Results: Compared with the normal group, there were significant differences in the four coagulation indexes (P <0.01). The levels of PT and KPTT in severe hepatitis group were significantly longer than those in other hepatitis groups (P <0.01) The most significant difference was found in the cirrhosis group (P <0.01), the four platelet indexes in the four groups (P <0.01), and the PLT and PCT groups were the most significant (P <0.01). Prompted the elderly chronic viral hepatitis may appear coagulation disorders and changes in platelet parameters, the combined application of various tests and dynamic observation, to assess the severity of liver damage is important
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