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目的:探讨前列腺特异抗原(PSA)、发射型计算机断层扫描(ECT)99Tc.MDP骨显像诊断前列腺癌骨转移的临床意义。方法:对80例(骨转移组3 1例,非骨转移组49例)前列腺癌患者的PSA、ECT与骨转移的关系进行分析。结果:骨转移组与非骨转移组的血清测试PSA值差异有显著性(139.36μg/L和37.58μg/L,P<0.01),与ECT全身骨显像,PSA与骨转移的程度正相关,血清PSA<10μg/L,ECT全身骨显像骨转移率为15.38%;血清PSA<20μg/L,ECT骨转移率为19.35%;血清PSA>20μg/L,ECT全身骨转移率为51.02%;血清PSA>100μg/L,ECT骨转移率为78.95%。结论:ECT骨显像对前列腺癌骨转移有较高的敏感性,对未经治疗的前列腺癌患者,血清测定PSA<10μg/L,前列腺癌骨转移的可能性极小;PSA>100μg/L,者,骨转移的可能性极大。PSA>20g/L,建议行ECT骨扫描。
Objective: To investigate the clinical significance of prostate specific antigen (PSA) and emission computed tomography (ECT) 99Tc.MDP bone imaging in diagnosis of bone metastasis of prostate cancer. Methods: The relationship between PSA, ECT and bone metastasis was analyzed in 80 cases (31 cases of bone metastasis and 49 cases of non-bone metastasis) of prostate cancer. Results: Serum PSA levels were significantly different between the bone metastasis group and the non-bone metastasis group (139.36μg / L and 37.58μg / L, P <0.01), which were positively correlated with the extent of whole body bone imaging, PSA and bone metastasis , Serum PSA <10μg / L, ECT total bone imaging bone metastasis rate was 15.38%; serum PSA <20μg / L, ECT bone metastasis rate was 19.35%; serum PSA> 20μg / ; Serum PSA> 100μg / L, ECT bone metastasis rate was 78.95%. Conclusions: ECT bone imaging is highly sensitive to bone metastasis of prostate cancer. Serum levels of PSA <10μg / L and minimal probability of prostate cancer bone metastasis are found in untreated prostate cancer patients. PSA> 100μg / L , The possibility of bone metastasis is extremely high. PSA> 20g / L, recommended ECT bone scan.