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为了预防急性心肌梗塞(AMI)并发心律失常,对29例病人进行随机双盲试验,静脉注射利多卡因(13例)和室安卡因(16例)。有胺类局部麻醉药物过敏、应用起搏器、口服抗心律失常药物或实验性药物的病人予以排除。病人入院后处理同其它AMI一样,然后采取随机双盲分组,全部病人均未出现症状性室性心动过速或心室颤动,仅1例应用利多卡因的病人发生心律失常而停止治疗。应用利多卡因和室安卡因的方法:是在2分钟内分别给予100毫克和250毫克,随后15分钟内分别再给60毫克和500毫克,然后每6小时分别静脉点滴1000毫克
To prevent acute myocardial infarction (AMI) complicated with arrhythmia, 29 patients were randomized, double-blind, intravenous lidocaine (13 patients) and ventricular card aneurism (16 patients). Patients with allergies to amine topical anesthetics who use pacemakers, oral antiarrhythmic drugs, or experimental medications should be excluded. Patients were admitted to hospital with the same treatment as other AMIs and then randomized to double-blind subgroups. None of the patients presented with symptomatic ventricular tachycardia or ventricular fibrillation. Only 1 patient who had lidocaine had an arrhythmia and discontinued treatment. The method of using lidocaine and ventricular card anecaine: 100 mg and 250 mg were given within 2 minutes, followed by another 60 mg and 500 mg within 15 minutes, and then intravenously every 1000 mg