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近年来,青霉素和其他有效抗菌素大大改变了细菌性心内膜炎的预后。对青霉素敏感的链球菌株(最低抑菌浓度MIC<0.2μgml)引起的心内膜炎,单用静脉青霉素1,000～2,000万单位/日的4周疗法,成人治愈率可达95～99％,缺点是住院时间太长,费用太贵。口服青霉素有效率为80％,有失败和复发,因而不被大家所接受。晚近采用青霉素、氨基糖甙(链霉素或庆大霉素)联合治疗2周的疗法能达到接近4周单用青霉素的治愈率。以往这种联合疗法主要用于治疗肠球菌(粪链球菌)心内膜炎,因为肠球菌对青霉素不敏感,临床
In recent years, penicillin and other effective antibiotics have greatly changed the prognosis of bacterial endocarditis. Endocarditis caused by penicillin-susceptible streptococcal strains (MIC <0.2μgml) is 95 to 99% with an adult cure rate of 1,000 to 20 million units / day intravenously with penicillin alone Hospitalization is too long, the cost is too expensive. Oral penicillin efficiency of 80%, there is failure and recurrence, which is not everyone accepted. Recent use of penicillin, aminoglycoside (streptomycin or gentamicin) combined treatment of 2 weeks of treatment can reach nearly 4 weeks cure rate of penicillin alone. In the past this combination therapy is mainly used for the treatment of enterococci (fecal streptococcal) endocarditis, because enterococci insensitive to penicillin, clinical