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用F60透析柱从胎牛骨髓中提取出一组分子量在10kD的多肽物质,以CorA诱导的淋巴细胞增殖反应研究其对小鼠T细胞功能的影响,发现该物质能促进ConA激活的小鼠淋巴细胞增殖反应。研究还发现,胎牛骨髓多肽在终浓度为5.0—10mg/ml时对人淋巴细胞表达mIL-2R有促进作用。从而提示该物质对机体细胞免疫功能具有促进作用。
A F60 dialysis column was used to extract a group of 10 kD peptide substance from fetal bovine bone marrow. The effect of CorA-induced lymphocyte proliferation on the T cell function of mice was investigated. The results showed that the substance promoted ConA-activated mouse lymphoid Cell proliferation response. The study also found that fetal bovine bone marrow peptide at a final concentration of 5.0-10mg / ml of human lymphocytes to promote the expression of mIL-2R role. Thus suggesting that the substance has a promoting effect on cellular immunity of the body.