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最早报告恶性疟原虫对抗疟药产生抗性的是1910年Nocht等在巴西发现对奎宁(quinine)产生了抗药性。以后又发现对乙胺嘧啶(Pyrimethamine)产生了抗药性。但都是很局限的,到了60年代初,又有报告,几乎同时在哥伦比亚、南美洲、泰国和东南亚出现了恶性疟原虫对当时广泛使用的抗疟药氯喹(Chloroquine)产生了抗药性。其后,抗氯喹虫株出现的范围不断扩大,产生抗药性的药物也不断增多。我国
The earliest reported resistance of Plasmodium falciparum to antimalarial drugs was that in 1910 Nocht et al. Found resistance to quinine in Brazil. Later, it was found that Pyrimethamine was resistant. But they were all very limited. By the early 1960s, it was reported that P. falciparum appeared almost at the same time in Colombia, South America, Thailand and Southeast Asia to become resistant to Chloroquine, a widely used antimalarial drug. Since then, the scope of resistance to chloroquine insects has been expanding, resulting in drug resistance drugs are also increasing. My country