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已知,癌的增殖,进展与增殖因子和其受体有密切关系。临床上有关表皮生长因子受体(EGFR)的发现与癌的恶性度报道多。文章对头颈部鳞癌行免疫组织学观察,就其EGFR与肿瘤恶性度的关系进行了研究。头颈部鳞癌68例,男57例,女11例,年龄23～82岁,平均60岁。其中口唇与口腔鳞癌16例,上、中下咽部癌分别为6例、7例和15例,喉癌10例,上颌窦瘤12例,其它2例。淋巴结转移者40例。将活检肿瘤标本包埋、速冻、切片等一系列处理后,光镜下观察。结果:EGFR(+)组32例,其中12例有淋巴结转移,
It is known that the proliferation and progression of cancer are closely related to proliferation factors and their receptors. There have been many clinical reports of the epidermal growth factor receptor (EGFR) findings and cancer malignancy. In this article, immunohistochemical observations of head and neck squamous cell carcinomas were carried out to investigate the relationship between EGFR and malignancy. Head and neck squamous cell carcinoma in 68 cases, 57 males and 11 females, aged 23 to 82 years old, an average of 60 years old. There were 16 cases of oral lips and oral squamous cell carcinoma, 6 cases of upper and middle hypopharyngeal cancer, 7 cases and 15 cases, 10 cases of laryngeal cancer, 12 cases of maxillary sinus tumor, and 2 cases. There were 40 cases of lymph node metastases. A series of treatments such as embedding, rapid freezing and slicing of the biopsy specimens were performed under light microscope. RESULTS: Thirty-two patients in the EGFR(+) group had lymph node metastases in 12 cases.