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早期的抗抑郁药研究着重于离体或急性给药后的作用观察。晚近则重点转移到观察慢性给药后所产生的效应。主要由于从给药开始到临床症状的改善有7～20天的潜伏期,有人报道,连续用丙咪嗪和去甲丙咪嗪的大鼠大脑皮层薄片对去甲肾上腺素(NA)提高~3H-
Early antidepressant research focused on the role of post-acute or acute administration. Later, the focus shifted to observe the effects of chronic administration. Mainly due to an incubation period of 7-20 days from the start of administration to the improvement of clinical symptoms, it has been reported that continuous administration of nalinine (NA) to rat cerebral cortex sheets with imipramine and desipramine improves ~ 3H -