活化的胰腺星状细胞(pancreatic stellate cells,PSCs)是胰腺炎致胰腺纤维化的主要效应细胞。近年来,学者普遍认为,胰腺纤维化早期阶段是动态可逆的,因此,若在胰腺损伤的早期阶段,抑制PSCs的增殖、迁移,减少损伤部位PSCs的数目,降低细胞外基质(extracellular matrix,ECM)的生成,将可能逆转胰腺纤维化。该文以PSCs为靶点阐述了抗胰腺纤维化的新策略。 Activated pancreatic stellate cells (PSCs) are the main effector cells of pancreatic fibrosis induced by pancreatitis. In recent years, scholars generally believe that the early stage of pancreatic fibrosis is dynamically reversible, so if the early stage of pancreatic injury, inhibition of proliferation and migration of PSCs, reduce the number of injured parts of PSCs, reduce the extracellular matrix (ECM ) Will likely reverse pancreatic fibrosis. In this paper, a new strategy of anti-pancreatic fibrosis is described with PSCs as the target.