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用离体大鼠心脏缺血再灌注模型,观察间硝苯啶和硝苯啶对左心室顺应性及收缩性能的保护作用。缺血30min复灌10min,左心室顺应性和增长压显著降低,左心室僵硬度常数显著增加(P<0.01)。预先ip间硝苯啶(m-Nif)或硝苯啶(Nil)60μg/kg bid×2d,离体灌注时,灌流给予0.5μmol/L m-Nif或Nif,20min可防止缺血再灌注后左心室顺应性、增长压和僵硬度常数的改变。m-Nif和Nif在作用强度上无显著差异。
The isolated rat heart ischemia-reperfusion model was used to observe the protective effects of m-nifedipine and nifedipine on left ventricular compliance and contractility. Reperfusion 10min after ischemia for 30min, left ventricular compliance and growth pressure decreased significantly, left ventricular stiffness constant increased significantly (P <0.01). Premedication of ip m-Nif or Nil 60 μg / kg bid × 2d, perfusion when given 0.5μmol / L m-Nif or Nif, 20min to prevent after ischemia-reperfusion Left ventricular compliance, changes in growth stress and stiffness constants. There was no significant difference in the intensity of action between m-Nif and Nif.